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We identified 1,057 prokaryotic species, thereby adding 531 species to the human gut repertoire: 146 bacteria known in humans but not in the gut, 187 bacteria and 1 archaea not previously isolated in humans, and 197 potentially new species

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This functional adaptation is facilitated by distinct M2 subtypes (M2a, M2b, M2c, M2d), classified based on activating stimuli and transcriptional profiles, each with specific functions (172)